"An enzyme and its substrate are traditionally compared to a lock and key, so protein/enzyme denaturation is like bending the key: It stops working."
A whole book of essential analogies it is.
METAMIA is a free database of analogy and metaphor. Anyone can contribute or search. The subject matter can be anything. Science is popular, but poetry is encouraged. The goal is to integrate our fluid muses with the stark literalism of a relational database. Metamia is like a girdle for your muses, a cognitive girdle.