"Looking at the protein's structure is like opening up a clock and understanding how all the parts fit together and work in unison," said co-author Joseph Noel. "With x-ray instruments from our lab at the Salk Institute, we looked at Orf2 from 30 feet away. With SSRL, we can look at it with a magnifying glass if we need to. That's an essential part of the whole process."
"..Seattle biochemist David Baker explains it, a protein's structure is like a ball on a sloping floor: It will find its lowest energy state just as the ball will naturally roll to the surface's lowest point. Figuring out the "correct" shape of a given protein, then means finding the shape with the lowest energy level."
METAMIA is a free database of analogy and metaphor. Anyone can contribute or search. The subject matter can be anything. Science is popular, but poetry is encouraged. The goal is to integrate our fluid muses with the stark literalism of a relational database. Metamia is like a girdle for your muses, a cognitive girdle.