nuclease

What:

"All human DNA repair processes require a nuclease to remove damaged DNA. Metaphorically speaking, a nuclease is like a surgical scalpel that removes the damaged tissue, but in this case the damage is at the molecular level in the DNA "

Writer: Michael R Lieber et al.

LCC:

Where:

Date: May 10 2014 10:08 AM

What: "The Nuclease is like the sent of your house. The sent of your house is like your DNA, like if you and your family smells like flowers then your house will likely smell flowers!"Nuclease specificity is like smell. Your nose can identify many different molecules based on their scent. Nucleases are enzymes with specificity for a particular sequence of nucleotides.

Writer: Devin Greenway

LCC:

Where:

Date: May 10 2014 10:15 AM

What:

"The logic can be seen by analogy to quality control along an assembly line. A polymerase is like a machine that makes widgets and sends them down the line at a certain rate. An exonuclease is like a worker responsible for removing defective widgets that come down the line. The worker sometimes removes perfect widgets by mistake. (The fewer such mistakes, the more "specific" the worker.) However, the number of defective widgets that get past the worker depends primarily on how many widgets the worker checks as the assembly line rolls by. If the assembly line slows down (i.e., there arises an impediment to forward translocation), the worker will be able to check more widgets and therefore let fewer defective ones go by. "

Writer: Myron F. Goodman D. Kuchnir Fygenson

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Where:

Date: May 1 2014 5:39 PM