messenger rna

What: "In other words, endothelin-1 messenger RNA is like tape-recorded instructions in a spy movie. Translated from RNA to English, the information is equivalent to " This message will self- destruct in five seconds." By ensuring destruction of endothelin-1 messenger RNA after the protein is produced, nature once again gets an arrow in the bull's-eye."

Writer: TIMOTHY G. STANDISH

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Date: Feb 24 2014 4:32 PM

What: "RNA polymerase uses the patterns in the bases as a guide for building a third compound: messenger RNA. Messenger RNA is like a genetic order form--it carries the recipe for a protein from the DNA to protein-building factories outside the nucleus."

Writer: Michael Purdy

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Date: Feb 24 2014 4:33 PM

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"Messenger RNA is like a ball of string; you need to know which areas are available for binding," says Darrin Disley, head of marketing at ExpressOn. "The current technology has you snip one base at a time, but a gene can have 10,000 bases so you have to do so many experiments. There's a very high failure rate; it's expensive and slow."

Writer: Darrin Disley

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Date: Feb 24 2014 4:34 PM

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"The problem, Darnell explains, is that the messenger RNA "is like a long coastline with a lot of ports, and it's been very difficult to know where the microRNA docks." Biochemical and computer prediction methods are imperfect, he says, and so the tedious hunt for binding sites could only be done experimentally, one RNA at a time."

Writer: Robert B. Darnell, MD, PhD

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Date: Feb 24 2014 4:31 PM