frameshift mutation

What:

"A frameshift mutation, is like taking out a letter in this sentence: the big cat ate the fat rat. If we take out one letter, for example, the t in "ate" everything downstream changes, it becomes: the big cat aet hef atr at. Why are all of the words in the first sentence 3 letters? Remember, mRNA (which came from DNA) is "read" 3 letters at a time, that's a codon. If one of the letters goes away, everything downstream of the mutation is affected. By the same token, if one letter is added, everything downstream is also changed. This guy on Youtube does a decent job with this concept in this 5 minute video. Note that he abbreviated the amino acids, for example, he represents Proline as simply "pro". It is standard in the industry to abbreviate. In his example, line 1, proline becomes arginine after the insertion of the "G" after the first "C" in proline. It is technically an insertion mutation that causes a frameshift- everything after the amino acid "asn" is wrong!"

Writer: Mrs. Plassio

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Where:

Date: Jun 11 2014 6:13 PM

What:

The video describes this shift very clearly.

Writer: Greg Petersen

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Where:

Date: Jun 11 2014 6:15 PM

What: A frameshift mutation is like taking a scantron test. If you accidentally get one question off every answer from then on will probably be wrong. Frameshift mutations radically change proteins. Most of the time they are quite deleterious.

Writer: Not Stated

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Where: Reference Link Has Evaporated

Date: Jun 11 2014 6:18 PM