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mutation

n=11
The Black Sheep, Pearl....

a: Mutation ~
b: black pearl in a necklace of white pearls

What: Or something. This analogy refers to a single point mutation, that is a single change in a DNA base that gives rise to a single amino acid change in a protein. The classic example is that taught in basic biochemistry, Sickle Cell Anemia. A single mutation in a gene leads to a change in an amino acid in Hemoglobin, which deforms the shape of these cells within human blood. Think of that change, that mutation , as a black pearl in a string of white pearls. That ones change can cause many physiological problems. This of course is the text book case. Many diseases are MUCH more complicated than this, but this example helps to realistically prime the mind.

Useful?
Writer: Lucretia
LCC: QP
Where: Reference Link Has Evaporated
Date: May 13 2013 11:41 AM



a: Permutation ~
b: ordered Combination

What:


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Writer: Not Stated
LCC:
Where:
Date: Jul 1 2016 2:53 PM



a: dna mutation ~
b: misspelled word

What:


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Writer: Me
LCC:
Where: Reference Link Has Evaporated
Date: Mar 26 2014 12:51 PM



a: gene mutation ~
b: spelling error

What:


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Writer: Not Stated
LCC:
Where:
Date: Apr 24 2016 7:46 PM



a: point mutation ~
b: a typo in the gene

What:

"A point mutation is like a typo in the gene that causes it to work incorrectly."


Useful?
Writer: Christine Kuehn Kelly
LCC:
Where:
Date: May 15 2014 5:24 PM


Butler Is Not Butter

a: point mutation ~
b: single letter in a word

What:

This type of mutation is not a major
change in a DNA sequence. But they usually occur at a key position within the gene. For example, a single point mutation in the protein coding region of a gene may have a deleterious effect on the creation of that protein.

The word spelling analogy may give a feel for this change. A single change in a letter in some words may change the word into something that is not recognized. For example , if "butler" is change to "butter", the meaning of that word is entirely different, even though only a single letter, l to t, has been modified.


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Writer: Lucrezia
LCC:
Where: Reference Link Has Evaporated
Date: May 15 2014 5:35 PM



a: BRCA1 mutation ~
b: cutting brake cable

What:

A a fault in BRCA1 "is like cutting the brake cable on a car"


Useful?
Writer: Dr Ramon Parsons
LCC:
Where:
Date: Sep 9 2014 10:18 AM


Viral Mutation Is Like A Murdered Changing....

a: Sars viral mutation ~
b: a murderer who is trying to change his fingerprints

What: "This rapid evolution is like that of a murderer who is trying to change his fingerprints or even his appearance to try to escape detection," said Dr. Dennis Lo, a chemical pathologist at the university.

Useful?
Writer: Dennis Lo
LCC: RB
Where:
Date: Aug 7 2011 10:56 AM



a: frameshift mutation ~
b: removing a letter from a sentence

What:

"A frameshift mutation, is like taking out a letter in this sentence: the big cat ate the fat rat. If we take out one letter, for example, the t in "ate" everything downstream changes, it becomes: the big cat aet hef atr at. Why are all of the words in the first sentence 3 letters? Remember, mRNA (which came from DNA) is "read" 3 letters at a time, that's a codon. If one of the letters goes away, everything downstream of the mutation is affected. By the same token, if one letter is added, everything downstream is also changed. This guy on Youtube does a decent job with this concept in this 5 minute video. Note that he abbreviated the amino acids, for example, he represents Proline as simply "pro". It is standard in the industry to abbreviate. In his example, line 1, proline becomes arginine after the insertion of the "G" after the first "C" in proline. It is technically an insertion mutation that causes a frameshift- everything after the amino acid "asn" is wrong!"


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Writer: Mrs. Plassio
LCC:
Where:
Date: Jun 11 2014 6:13 PM



a: frameshift mutation ~
b: this video

What:

The video describes this shift very clearly.


Useful?
Writer: Greg Petersen
LCC:
Where:
Date: Jun 11 2014 6:15 PM


You searched for: mutation
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