The Black Sheep, Pearl....
a: Mutation ~
b: black pearl in a necklace of white pearls
What: Or something. This analogy refers to a single point mutation, that is a single change in a DNA base that gives rise to a single amino acid change in a protein. The classic example is that taught in basic biochemistry, Sickle Cell Anemia. A single mutation in a gene leads to a change in an amino acid in Hemoglobin, which deforms the shape of these cells within human blood. Think of that change, that mutation , as a black pearl in a string of white pearls. That ones change can cause many physiological problems. This of course is the text book case. Many diseases are MUCH more complicated than this, but this example helps to realistically prime the mind.
Writer: Lucretia
LCC: QP
Where: Reference Link Has Evaporated
Date: May 13 2013 11:41 AM
a: Permutation ~
b: ordered Combination
Writer: Not Stated
LCC:
Where:
Date: Jul 1 2016 2:53 PM
a: dna mutation ~
b: misspelled word
Writer: Me
LCC:
Where: Reference Link Has Evaporated
Date: Mar 26 2014 12:51 PM
a: gene mutation ~
b: spelling error
Writer: Not Stated
LCC:
Where:
Date: Apr 24 2016 7:46 PM
a: point mutation ~
b: a typo in the gene
What:
"A point mutation is like a typo in the gene that causes it to work incorrectly."
Writer: Christine Kuehn Kelly
LCC:
Where:
Date: May 15 2014 5:24 PM
Butler Is Not Butter
a: point mutation ~
b: single letter in a word
What:
This type of mutation is not a major
change in a DNA sequence. But they usually occur at a key position within the gene. For example, a single point mutation in the protein coding region of a gene may have a deleterious effect on the creation of that protein.
The word spelling analogy may give a feel for this change. A single change in a letter in some words may change the word into something that is not recognized. For example , if "butler" is change to "butter", the meaning of that word is entirely different, even though only a single letter, l to t, has been modified.
Writer: Lucrezia
LCC:
Where: Reference Link Has Evaporated
Date: May 15 2014 5:35 PM
a: BRCA1 mutation ~
b: cutting brake cable
What:
A a fault in BRCA1 "is like cutting the brake cable on a car"
Writer: Dr Ramon Parsons
LCC:
Where:
Date: Sep 9 2014 10:18 AM
a: silent mutation ~
b: a neutral mutation
What:
"A silent mutation is like a neutral mutation except the codon change does not result in an amino acid change"
Writer: Nicholas W. Gillham
LCC:
Where:
Date: Jan 20 2018 5:02 PM
a: silent mutation ~
b: changing the words in a book
What:
But it is a book in the basement of a library that no one every looks for and no one every reads.
Writer: Not Stated
LCC:
Where: Reference Link Has Evaporated
Date: Jan 20 2018 5:05 PM
a: neutral mutation ~
b: a missense mutation
What:
"A neutral mutation is like a missense mutation except that the amino acid change does not affect the function of the protein. A silent mutation is like a neutral mutation except the codon change does not result in an amino acid change. Nonsense mutations replace a codon specifying an amino acid in protein with UAG, UGA, ..."
Writer: Nicholas W. Gillham
LCC:
Where:
Date: Jan 20 2018 5:07 PM
