"At the halfway point between it's folded and unfolded state, a protein is like a rollercoaster balanced at the crest of the highest hill on the track. Like the rollercoaster, the protein requires a certain amount of energy to make it over the hill and wind its course to a final resting place -- its folded state. If it lacks the energy to clear the hill, it will slide back into a partially folded or misfolded state. "