"The HGP killed the status of medicinal chemists because it revealed that structure does not equal function and the assumption of linear pathways turned out to be naive. Medicinal chemists are like a craftsman behind an old manual lathe. The human brain cannot understand mechanism through naive experimental design. Mechanism must be inferred through computational methods + improved automated instrumentation. Physics + mathematics is now driving drug discovery. Look at the new microarray driven biomarkers!"
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